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【院长论坛】Protein tyrosine phosphatases in cancer: targeting PTP1B and TC-PTP enzymes

发布日期:2009-05-07    浏览次数:
报告题目:Protein tyrosine phosphatases in cancer: targeting PTP1B and TC-PTP enzymes
报告人:Michel L. Tremblay, Ph.D., F.R.S.C.
        Director, McGill Cancer Center, McGill University,Canada
时间:2009年5月11日下午2:00
地点:医学部会议中心205室
主持人:尹玉新教授(北京大学基础医学院院长)
 
                               北京大学基础医学院
                             
报告人简介:
Dr. Michel L. Tremblay is a Jeanne and J.-Louis Lévesque Chair in Cancer Research and James McGill Professor in McGill University, Montreal, Quebec, Canada. Dr. Tremblay is a world leader in the field of protein tyrosine phosphatases (PTPases) and has made tremendous contributions to our understanding of the role of protein tyrosine phosphatases in signaling transduction and tumor development. Protein tyrosine phosphatases are implicated in a variety of cellular processes such as cell proliferation, apoptosis and differentiation.  Dr. Tremblay’s laboratory employs a variety of tools in the analysis of these PTPases. These include: cloning and identification of tissue specific and developmentally regulated PTPases; identification of in vivo substrates, associated proteins, and extracellular ligands; creation of temperature sensitive enzymes and cell lines; and the analysis of the gene expression pattern during mouse development. Together with transgenic and "knockout" mouse technology, these tools allow us to asses the role of these genes during mouse development as well as cellular events involved in cancer.
HONOURS and AWARDS:
1984-1986 National Cancer Institute of Canada Studentship
1984-1986 Harry Lyman Hooker Graduate Scholarship
1987-1990 National Cancer Institute of Canada Fellowship
1990-1992 NIH Fogarty Fellow
1992-1995 Fraser, Monat and McPherson Scholarship
1994-1998 Chercheur- Boursier Junior II, FRSQ, Investigator’s award
1998-2002 Chercheur- Boursier Senior, FRSQ (Investigator’s award)
2000-2005 Medical Research Council, MRC Scientist Award
November 2002 Ambassador, Université de Sherbrooke, Quebec
2003-present McGill Medical Ambassador, McGill University
2004–2010 James McGill Professor, McGill University
2005-2010 FRSQ Chercheurs Nationaux
2005-present Jeanne and J.-Louis Lévesque Chair in Cancer Research
2006-present Fellow, Royal Society of Canada